[Frontiers in Bioscience 2, e99-107, November 1, 1997]
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LACCASE AND MELANIN IN THE PATHOGENESIS OF CRYPTOCOCCUS NEOFORMANS

Peter R. Williamson

Division of Infectious Diseases, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612

Received 10/20/97 Accepted 10/24/97

1. Abstract
2. Introduction
3. Melanin biosynthesis of c. neoformans
4. Phenol oxidase activity of c. neoformans
5. Cryptococcus neoformans and the role of melanin in virulence
6. Molecular mechanisms of pathogenesis
7. The mechanism of melanin in protection against immune effectors
8. Melanin biosynthesis and the ecological niche of cryptococcus
9. Acknowledgments
10. References
11. Entire manuscript

Key words: Infection, Pathogenesis, Cryptococcus neoformans, Melanin, Laccase