[Frontiers in Bioscience 3, d169-175, February 15, 1998]
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FREE FATTY ACIDS (FFA), A LINK BETWEEN OBESITY AND INSULIN RESISTANCE

Guenther Boden, M.D.

Division of Endocrinology/Diabetes/Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, PA

Received 1/21/98 Accepted 1/31/98

TABLE OF CONTENTS


1. Abstract
2. Introduction
3. Insulin Resistance. Definition.
4. FFA and Peripheral Insulin Resistance
4.1. Effect of FFA on Basal Glucose Uptake
4.2. Effect of FFA on Insulin Stimulated Glucose Uptake
4.3. Cellular Location of FFA Induced Defects
4.4. Mechanisms

5. FFA and Hepatic Insulin Resistance
6. Significance
7. Acknowledgement
8. References
9. Entire manuscript

Key words: Insulin, Fatty acids, Obesity, Diabetes