[Frontiers in Bioscience 3, d176-193, February 15, 1998]
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REGULATION OF BILE ACID SYNTHESIS 

John Y. L. Chiang

Department of Biochemistry and Molecular Pathology, Northeastern Ohio Universities College of Medicine, P. O. Box 95, Rootstown, OH 44272

Received 1/22/98 Accepted 2/2/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Bile Acid Biosynthesis Pathways
3.1. Classic Pathway
3.2. Alternative pathway
4. Major enzymes in Bile Acid Synthesis
4.1. Cholesterol 7alpha-hydroxylase
4.1.1. Bile acid feedback
4.1.2. Role of cholesterol
4.1.3. Hormonal regulation
4.1.4. Diurnal rhythm
4.1.5. Other factors
4.1.6. Regulation of the CYP7A gene expression
4.1.7. Molecular Mechanisms of regulation
4.2. Sterol 27-hydroxylase
4.3. Oxysterol 7alpha-hydroxylase
4.4. Sterol 12alpha-hydroxylase
5. Conclusion and Future Perspective
6. Acknowledgment
7. References
9. Entire manuscript

Key words: Bile acid synthesis, Cytochrome P450, cholesterol 7alpha-hydroxylase, Sterol 27-hydroxylase, Sterol 12alpha-hydroxylase, Oxysterol 7alpha-hydroxylase, Gene regulation, Gene transcription