[Frontiers in Bioscience 3, d327-337, March 21, 1998]
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ALZHEIMER’S DISEASE AND HEPARAN SULFATE PROTEOGLYCAN

Ken-ichiro Fukuchi, Michael Hart, and Ling Li

Department of Comparative Medicine, University of Alabama at Birmingham, Birmingham Alabama 35294-0019

Received 3/5/98 Accepted 3/9/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion
3.1. Chemistry of heparan sulfate proteoglycan
3.2. Chemical composition of heparan sulfate in Alzheimer’s disease
3.3. Immunohistochemical localization of heparan sulfate proteoglycan
3.4. Beta-amyloid protein and its precursor protein
3.5. Beta-amyloidosis and heparan sulfate proteoglycan
3.5.1. Interaction between beta-amyloid protein and heparan sulfate proteoglycan
3.5.2. Rat infusion models of brain amyloidosis
3.5.3. Processing of amyloid precursor protein and heparan sulfate proteoglycan
3.5.4. Beta-amyloid clearance and heparan sulfate proteoglycan
3.6. Neurite outgrowth and heparan sulfate proteoglycan
3.7. Neurofibrillary tangles and heparan sulfate proteoglycan
3.8. Apolipoprotein and heparan sulfate proteoglycan

4. Perspective
5. Acknowledgments
6. References
7. Entire manuscript

Key words:Heparan sulfate, Proteogycan, Alzheimer’s disease, Amyloid, Amyloidosis, Beta-amyloid protein, perlecan, Amyloid precursor protein, Neurofibrillary tangles, Neuritic plaques, Tau, Apolipoprotein, Protein processing, Etiology, Immunohistochemistry

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