[Frontiers in Bioscience 3, d1171-1180, November 15, 1998]
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CAVEAT LECTOR




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HOST SUSCEPTIBILITY FACTORS TO CUTANEOUS LEISHMANIASIS

Douglas E. Jones, M. Merle Elloso and Phillip Scott

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Received 10/26/98 Accepted 10/30/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Parasite Life Cycle
4. Human Leishmaniasis
5. Experimental Models of Leishmaniasis
6. Killing the Parasite; Macrophage Activation
6.1 Cytokines and Macrophage Activation
6.2 The Macrophage and T Cell Interactions
6.3 Macrophage Activation and Susceptibility versus Resistance
7. Cell-Mediated Immunity
7.1 Factors that Promote Th1 Cell Development
7.2 Sources of IL-12
7.3 IL-12 responsiveness
7.4 Immunomodulation with IL-12
8. The T Helper 2 Response
9. Other Leishmania Species
10. Conclusions
11. Acknowledgements
12. References
13. Entire manuscript

Key words: Infection, Leishmaniasis, Leishmania, Cytokines, Immune system

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