[Frontiers in Bioscience 3, d604-615, July 1, 1998]
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THE ROLE OF CD44 AS A CELL SURFACE HYALURONAN RECEPTOR DURING TUMOR INVASION OF CONNECTIVE TISSUE

Warren Knudson

Department of Biochemistry, Department of Pathology, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612-3864

Received 4/27/98, Accepted 5/15/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Tumor-associated hyaluronan
3.1. Structure and synthesis of tumor-associated hyaluronan
3.2. Preferential enrichment of tumor tissue with hyaluronan
3.3. Is the level of hyaluronan content in tumor progression of diagnostic or prognostic value?
4. The function of tumor-associated hyaluronan
4.1. Hyaluronan and cell migration: A function by association
4.2. Proposed mechanisms for the involvement of hyaluronan in cell migration and proliferation
5. The role of CD44 as a hyaluronan receptor during tumor progression
6. Acknowledgments
7. References
8. Entire manuscript

Key words: CD44, Hyaluronan, Tumor, Invasion, Receptor, Connective tissue