[Frontiers in Bioscience 3, d1148-1160, November 15, 1998]
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CAVEAT LECTOR




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MOLECULAR PATHOBIOLOGY OF PANCREATIC ADENOCARCINOMA

Shamlal Mangray and Thomas C King

Department of Pathology and Laboratory Medicine, Brown University School of Medicine, Providence, RI

Received 8/24/98 Accepted 9/4/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Heritable pancreatic cancer
3.1. Genetic syndromes predisposing to pancreatic adenocarcinoma
3.1.1. Hereditary pancreatitis
3.1.2. Ataxia telangiectasia
<3.1.3. FAMMM syndrome
3.1.4. Hereditary nonpolyposis colorectal cancer
3.1.5. Peutz-Jegher's syndrome
3.2. Familial pancreatic cancer
3.3. Pancreatic adenocarcinoma risk in families with other sporadic cancers
4. Chromosomal abnormalities in pancreatic adenocarcinoma
5. Genetic alterations in pancreatic adenocarcinoma
5.1. K-ras proto-oncogene
<5.2. p16INK4a /p15INK4b/p19ARF tumor suppressor genes
5.3. p53 tumor suppressor gene
<5.4. DPC4 (Smad4) tumor suppressor gene
5.5. FHIT, fragile histidine triad, candidate tumor suppressor gene
<5.6. HER-2/neu (erbB2) proto-oncogene
<5.7. BRCA2, hereditary breast Cancer
5.8. Rb1, retinoblastoma tumor suppressor gene
6. Diagnostic implications
7. Therapeutic implications
8. Perspective
9. References
10. Entire manuscript

Key words: Pancreatic Adenocarcinoma, Molecular Biology, p16, p53, K-ras, FHIT