[Frontiers in Bioscience 7, e1-8, January 1, 2002]

TARGETING ACTIN REMODELING PROFILES FOR THE DETECTION AND MANAGEMENT OF UROTHELIAL CANCERS - A PERSPECTIVE FOR BLADDER CANCER RESEARCH

JianYu Rao

Department of Pathology and Laboratory Medicine, University of California at Los Angeles Medical Center, Los Angeles, CA 90095

FIGURES

Figure 1. Molecular progression pathways for bladder cancer.

Figure 2. Actin involvement in forcal adhesion (modified from Ref (5)).

Figure 3. Actin signaling (adapted from Ref. (4)).

Figure 4. Actin associated molecules implicated in malignant transformation.

Figure 5. Actin remodeling in transformation

enhances apoptosis induction in both chemotherapeutic sensitive and resistant malignant cells (35, 36).

Figure 6. Apoptotic machinery.

Figure 7. A hypothetical model of how actin function as a switch in transformation and cell death process.

Figure 8. Actin based bladder cancer detection and management schema.