[Frontiers in Bioscience 8, d855-869, May 1, 2003]

FUNCTION OF BONE MORPHOGENETIC PROTEIN SIGNALING DURING MOUSE DEVELOPMENT

Yuji Mishina

Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxycology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA

FIGURES

Figure 1. BMP receptors are membrane bound Ser/Thr kinases

Figure 2. Binding Specifity of the TGF-beta superfamily receptors.

Figure 3. Constitutece Active Type I receptors send signals without ligands or type II receptors. Dominant Negative Type I receptors block BMP signaling.

Figure 4. Function of BMP signaling in L-R asymmetry.