[Frontiers in Bioscience 8, d603-619, May 1, 2003]
RETROVIRAL TECHNOLOGY - APPLICATIONS FOR EXPRESSED PEPTIDE LIBRARIES
Roland Wolkowicz, and Garry P. Nolan
Department of Microbiology and Immunology, Baxter Laboratory in Genetic Pharmacology, Stanford University Medical Center, Stanford, California
TABLE OF CONTENTS
The cell is an extremely complex network of interactions between large numbers of molecules. Understanding this entire network and the information arising from it is an overwhelming and challenging task. Reverse genetics has given us the possibility to discover unknown interactions and their related pathways. With the help of peptide libraries, interactions between biomolecules can be disrupted or distorted and the signaling pathways where these proteins are involved, altered. Consequently, novel biological pathways can be discerned.