[Frontiers in Bioscience 11, 1189-1198, January 1, 2006]

DNA vaccines for cancer

Denise R. Shaw and Theresa V. Strong

Department of Medicine, Division of Hematology and Oncology, and the Comprehensive Cancer Center, University of Alabama at Birmingham

TABLES

Table 1. Strategies to Enhance the Efficacy of Polynucleotide Vaccines for Cancer Therapy

Aspect of Vaccine

Intervention

References

Nucleic acid delivery

  • Liposomes
  • PLG microparticles
  • Electroporation
  • Hydrodynamic delivery

43

44

45,46

47

Modification of the antigen to target APCs

  • Fuse antigen with
  • CD40L, Flt-3L, CTLA4

49-51

Modification of the antigen to increase immunogencity

  • Alter antigen processing
  • Incorporate immunogenic eptiopes
  • Use antigen from a different species
  • Codon optimization

52-54

55

67-71

56

Modification of the microenviroment

  • Cytokine codelivery
  • Chemokine codelivery

58-60

61,62