[Frontiers in Bioscience E1, 537-541, June 1, 2009]

Cerebellar haemorrhages and pons development in extremely low birth weight infants

Monica Fumagalli1, Luca Antonio Ramenghi1, Andrea Righini2, Michela Groppo1, Laura Bassi1, Agnese De Carli1, Cecilia Parazzini 2, Fabio Triulzi 2, Fabio Mosca1

1Neonatal Intensive Care Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, University of Milan, Italy, 2Department of Radiology and Neuroradiology, Ospedale Pediatrico, Buzzi, ICP, Milan, Italy

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Materials and Methods
3.1. Statistical analysis
4. Results
5. Discussion
6. References

1. ABSTRACT

Neuropathological and Magnetic Resonance Imaging (MRI) studies showed a high frequency of posterior fossa abnormalities in preterms. To assess whether cerebellar haemorrhages (CH) diagnosed with ultrasound and/or MRI affect pons development in ELBW infants. The anteroposterior diameter of the pons was measured manually on the midline sagittal T1 MR image in 75 ELBW babies consecutively scanned at term postmenstrual age. Subjects with CH were identified and compared to babies with no posterior fossa bleeding. Nine ELBW infants with CH (CH-Group: median gestational age -GA- 26 wks, range 23-27; birth weight -BW- 680 g, 425-980) were compared with 66 babies with normal cerebellum (Control-Group: GA 28 wks, 23-33; BW 815 g, 430-1000). The two groups were comparable for BW (p=0.088) while GA was significantly shorter in CH babies (p=0.005). The pontine diameter was significantly lower in CH-Group compared to Control-Group (12.8 ± 2.2 vs 14.8 ± 1.2 mm; p<0.001). Conclusions: Cerebellar haemorrhages seem to affect the development of the pons in ELBW with the youngest GA.