[Frontiers in Bioscience S1, 23-32, June 1, 2009]

Tendon tissue engineering with mesenchymal stem cells and biografts: an option for large tendon defects?

Xiao Chen1,4, Xiao Hui Zou 3, Guo Li Yin 1,4, Hong Wei Ouyang 1, 2,4

1 Tissue Engineering Center, School of Medicine, Zhejiang University, Hangzhou, P.R..China, 2Department of Orthopedic Surgery, Sir RawRaw Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, P.R..China, 3 Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, P.R.China, 4 Institute of Cell Biology, School of Medicine, Zhejiang University, Hangzhou,P.R..China


1. Abstract
2. Introduction
3. MSCs as seed cells for tendon repair
4. MSCs based tendon tissue engineering
5. Decellular grafts for tendon repair 5.1. Grafts accepted in current clinical practice
5.2. Current researches on the decelullar technology and immunogenicity of biografts 6. MSCs revitalized decellular grafts 6.1. Current researches on the repopulation of tendon grafts
6.2. MSCs cell sheet repopulated tendon allograft 7. Future directions
8. Acknowledgment
9. Reference


The most important factors in the tissue engineering approach to tissue repair and regeneration are the use of appropriate cells and scaffolds. Mesenchymal stem cells (MSCs) are one of the most promising seed cells, which can be easily derived and have the potential to differentiate into various mesenchymal cell types as well as tenocytes in vitro and in vivo. Biological tendon grafts are the most common choice in current clinical practice, as they possess physical structure, strength and biocompatibility. We review the latest research findings on MSC-based tendon tissue engineering and recent advances in biological graft research.