[Frontiers in Bioscience 15, 57-64, January 1, 2010]

Functional genomics in identification of drug targets in Dupuytren's contracture

Mirela Sedic1, Davor Jurisic2,Zdenko Stanec3, Karlo Hock1, Kresimir Pavelic1,4, Sandra Kraljevic Pavelic1,4

1Rudjer Boskovic Institute, Division of Molecular Medicine, Laboratory for systems biology, Bijenicka c. 54, 10000 Zagreb, Croatia, 2University Hospital Center Rijeka, Clinic for Surgery, Department for Plastic and Reconstructive Surgery, Kresimirova 42a, 51000 Rijeka, Croatia, 3University Hospital Dubrava, Clinic for Plastic, Reconstructive and Aesthetic Surgery, Avenija Gojka Suska 6, 10 000 Zagreb, Croatia, 4University of Rijeka, Department of, Trsat, 51000 Rijeka, Croatia, Croatia


Table 1. Molecular factors known to be involved in development of Dupuytren's contracture

Growth factors

TGF-a and TGF-b

EGF (Epidermal growth factor)

PDGF (Platelet-derived growth factor)

Growth factor receptors

EGF-R (Epidermal growth factor receptor)

Transcription factors

Zinc finger protein 9

Metalloproteinase enzymes and their inhibitors

MMP-2 (Matrix metalloproteinase 2)

TIMP (Tissue inhibitors of metalloproteinases)

Extracellular matrix components

Collagen type III (immature form)



Immune system



GM-CSF (Granulocyte-macrophage colony-stimulating factor)

Oxidative stress

Oxygen free radicals