[Frontiers in Bioscience E2, 122-126, January 1, 2010]

A review of autoimmune diseases associated with cancer

Patricia Tai1, Edward Yu2, Kurian Joseph3, Thomas Miale4

1Faculty of Oncology, University of Saskatchewan, Saskatchewan; 2Department of Radiation Oncology, University of Western Ontario, London; 3Department of Radiation Oncology, University of Edmonton, Alberta; 4Department of Pediatric Oncology, Allan Blair Cancer Clinic, Saskatchewan, Canada


1. Abstract
2. Introduction
3. Autoimmune diseases associated with increased cancer risk
3.1. Rheumatoid arthritis (RA)
3.2. Systemic lupus erythematosus (SLE)
3.3. Sjögren's syndrome (SS)
3.4. Celiac disease (Non-tropical sprue)
4. Autoimmune phenomenon with cancers - paraneoplastic syndromes
4.1. Neurological
4.1.1. Neuromuscular junction disorders Lambert-Eaton myasthenic syndrome (LEMS) Myasthenia Gravis (MG)
4.1.2. Dermatomyositis and polymyositis
4.2. Hematological
5. New perspectives on cancer vaccines
6. References


The focus of this review is on the relationships between autoimmune diseases and cancer from two closely related perspectives: 1.Those autoimmune diseases which are often associated with malignancies. 2.Those prevalent cancers which may increase the risks of developing autoimmune disorders. The review concludes with a brief discussion of some selected innovative approaches to cancer immunotherapy.