[Frontiers in Bioscience E2, 159-164, January 1, 2010]

S100B protein and near infrared spectroscopy in preterm and term newborns

Lucia Gabriella Tina1, Alessandro Frigiola2, Raul Abella2, Paolo Tagliabue3, Luisa Ventura3, Giuseppe Paterlini3, Giovanni Li Volti4, Serena Pinzauti5, Pasquale Florio5, Valentina Bellissima6, Carlo Minetti6, Diego Gazzolo6,7

1Department of Maternal, Fetal and Neonatal Medicine, G. Garibaldi Hospital, Catania, 2Perinatal Research Laboratory, Department of Cardiac Surgery, S. Donato Milanese University Hospital, S. Donato Milanese; 3Department of Fetal Maternal and Neonatal Medicine, San Gerardo Hospital, Monza, 4Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania, Italy, 5Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, 6,Departments of Fetal Maternal and Neonatal Medicine C. Arrigo Children's Hospital, Alessandria, Italy,7Pediatrics and Neuroscience Giannina Gaslini Children's University Hospital, Genoa, Italy


1. Abstract
2. Introduction
3. Materials and methods
3.1. Population
3.2. Monitoring of cerebral oxygenation using NIRS
3.3. Standard monitoring parameters
3.4. Statistical analysis
4. Results
4.1. rSO2 and FTOE recordings
4.2. S100B measurements
5. Discussion
6. Acknowledgements
7. References


Cerebral monitoring constitutes an emerging issue in perinatal medicine. Near Infrared Spectroscopy (NIRS) monitors brain oxygenation status in sick infants although data in healthy infants are lacking. The present study investigates whether NIRS parameters change according to gestational age and correlate with S100B protein. We recruited 64 healthy newborns (weeks' gestation: 30-42 wks) in which we performed in the first 6-hours after birth routine clinical, radiological and laboratory variables, cerebral oxygen saturation (rSO2), fractional cerebral tissue oxygen extraction (FTOE) values and S100B urine assessment. rSO2 and FTOE correlated (R=-0.73; R=0.51; P less than 0.01, for both) with gestational age. Highest rSO2 and the lowest FTOE peaks (P less than 0.001) were found at 30-33 wks. From 34 wks onwards, rSO2 progressively decreased and FTOE increased reaching their lower dip/peak (P less than 0.001) at 38-39 weeks. A significant correlation between S100B and NIRS parameters (rSO2: r=0.77; FTOE: r=-0.69; P less than 0.01) has been found. The present study shows that NIRS parameters and S100B protein correlation may be of help in brain function monitoring.