[Frontiers in Bioscience S2, 969-979, June 1, 2010]
Regulation of T cells in airway disease by beta-agonist
Matthew J. Loza, Raymond B. Penn
Department of Medicine, Division of Pulmonary & Critical Care Medicine University of Maryland School of Medicine, Baltimore MD 21201
TABLE OF CONTENTS
It is widely recognized that Th2 cytokines derived from T cells play a major role in the development of allergic lung inflammation that causes most asthma. Beta-agonists are important rescue and maintenance therapies for asthma, yet our understanding of beta-agonist effects on T cell biology is surprisingly poor. Recent studies using both cell culture and more integrative models are beginning to reveal beta-agonist regulation of T cell signaling and function that may be important in the pathogenesis and treatment of asthma and possibly other inflammatory diseases. Here we provide a comprehensive review of the literature concerning beta-agonist effects on T cells, and discuss the relevance of emerging paradigms of beta-adrenergic receptor signaling to T cell function.