[Frontiers in Bioscience S2, 5-10, January 1, 2010]

Animal ethics in SIRS research

Punam Dahiya1, Bryan E. Ogden2

1Food and Veterinary Administration, Agri-Food and Veterinary Authority of Singapore, 5 Maxwell Road, #02-03, Tower Block, MND Complex, Singapore 069110, 2Maccine Pte. Ltd, 10 Science Park Road,Singapore Science Park II, #01-05 The Alpha, Singapore 117684


1. Abstract
2. Introduction
3. Guiding principles of animal research
3.1. The '3 Rs': replacement, reduction and refinement
3.2. Humane endpoints
3.3. IACUC: institutional animal care and use committee
3.4. Regulatory requirements
3.4.1. Regulations in the United States
3.4.2. Regulations in Singapore
4. Summary and perspective
5. References


It is well recognized that animals play a vital role and are indispensable to scientific and medical research. Over the years, a number of non-animal procedures have been developed. However, despite all the advances in science, as yet, no system has been evolved which can completely replace a living system to conduct basic research. There is still a need to test food, drugs, medical devices, treatment regimes etc. on some animals before they can be tested and used (if found suitable) in human beings. Even the most sophisticated technology models have failed to mimic completely the complex cellular interactions occurring in a living system. The search for a complete alternative to animal research is still on and in the mean time we can all help play our part by conducting animal research in a humane and responsible fashion. This chapter discusses the ethical issues in animal research highlighting the need to use animals conscientiously.