[Frontiers in Bioscience S2, 153-167, January 1, 2010]
Chemokines and chemokine receptors in arthritis
Zoltan Szekanecz1, Aniko Vegvari1, Zoltan Szabo1, Alisa E. Koch2,3
1Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary, Europe, 2Veterans' Administration, Ann Arbor Healthcare System, Ann Arbor, Michigan, USA, 3University of Michigan Health System, Department of Internal Medicine, Division of Rheumatology, Ann Arbor, Michigan, USA
TABLE OF CONTENTS
Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. Chemokines may also be either inflammatory or homeostatic, however, these functions often overlap. Anti-chemokine and anti-chemokine receptor targeting may be therapeutically used in the future biological therapy of arthritis. Most data in this field have been obtained from animal models of arthritis as only very few human RA trials have been completed. However, it is very likely that various specific chemokine and chemokine receptor antagonists will be developed and administered to RA patients.