[Frontiers in Bioscience E3, 945-954, June 1, 2011]

Inflammatory bowel disease in the geriatric population

Yahya Murad1, Zaher A. Radi2, Mohammed Murad3, Karen Hall4

1University of Michigan- Geriatrics Center, 4260 Plymouth Road, Ann Arbor, MI 48109 USA,2 Pfizer Worldwide Research and Development, 35 CambridgePark Dr., Cambridge, MA 02140 USA,3 University of Glasgow- Glasgow Dental Hospital, Restorative Department, 378 Sauchiehall Street, Glasgow G2 3JZ, UK,4 Geriatric Research, Education, and Training Center (GRECC), Ann Arbor VAHS, Ann Arbor, MI 48105 USA


1. Abstract
2. Introduction
3. Epidemiology
4. Pathophysiology
4.1. Crohn's disease
4.2. Ulcerative colitis 5. Clinical manifestations and diagnosis
5.1. Challenges
5.2. Changes in bowel habits
5.3. Extraintestinal manifestations
5.4. Orofacial manifestations
6. Prognosis and quality of life
7. Treatment
7.1. Aminosalicylates
7.2. Corticosteroids therapy
7.3. Thiopurine antimetabolites
7.4. Infliximab
7.5. Cyclosporine
8. Potential future research directions
9. References


Inflammatory bowel disease (IBD) is a chronic disease that affects not only the young adults, but also the elderly. The elderly are more vulnerable and at higher risk from complications related to IBD. In this review we focus on IBD important features in the elderly and discuss the disease (1) epidemiology, (2) pathophysiology, (3) clinical manifestations and diagnosis, (4) prognosis, (6) therapy and (7) potential future research directions.