[Frontiers in Bioscience E3, 1169-1181, June 1, 2011]
Principles, applications, risks and benefits of therapeutic hyperthermia
Riadh W. Y. Habash1, Daniel Krewski1, Rajeev Bansal2, Hafid T. Alhafid3
1McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada, 2Department of Electrical and Computer Engineering, University of Connecticut, Connecticut, USA, 3College of Engineering and Applied Sciences, Al Ghurair University, Dubai, UAE
TABLE OF CONTENTS
Hyperthermia as a heat therapy is the procedure of raising the temperature of a part of or the whole body above normal for a certain period of time. Based largely on delivery methods, therapeutic hyperthermia falls under three major categories: local, regional, and whole-body. It may be applied alone or jointly with other modalities such as radiotherapy, chemotherapy, radiochemotherapy, and gene therapy. Because of the individual characteristics of each type of treatment, different types of heating systems have evolved. This paper provides an overview of possible mechanisms of heat-induced cell death and the way heating exerts its beneficial effect. It also discusses various heating devices as well as other modalities used with hyperthermia. The paper concludes with a summary of benefits and risks, obstacles encountered in the treatment process, and future research directions.