[Frontiers in Bioscience S3, 1021-1031, June 1, 2011]
Neural regulation of bone, marrow, and the microenvironment
Jonathan Canaani1,2, Orit Kollet1, Tsvee Lapidot1
1Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel, 2Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239
TABLE OF CONTENTS
Bone marrow niches are specialized microenvironments comprising a heterogeneous population of cells that support and regulate hematopoietic stem and progenitor cells. Considerable advances made in the field of hematopoiesis reveal a cross talk between cells, cytokines and neurotransmitters of the hematopoietic, immune and skeletal systems. Dynamic modulation and regulation of stem cells and their niches in response to internal and external stimuli are essential for homeostasis, host defense and repair. This review presents evidence to substantiate stem cell regulation via the "brain-bone-blood triad" beginning at the embryonic stage and continuing to adulthood.