[Frontiers in Bioscience S3, 1080-1088, June 1, 2011]

Lactoferrin and cancer in different cancer models

Jessica A. Gibbons1, Rupinder K. Kanwar1, Jagat R. Kanwar1

1Laboratory of Immunology and Molecular Biomedical Research (LIMBR), Centre for Biotechnology and Interdisciplinary Biosciences (BioDeakin), Institute for Technology and Research Innovation (ITRI), Deakin University, Geelong, Technology Precinct (GTP), Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Lactoferrin, cancer and culture models
3.1. Lactoferrin
3.2. Molecular structure and mechanism
3.3. Expression
3.4. Lactoferrin and immunity
3.5. Lactoferrin and digestion
3.6. Oral lactoferrin
3.7. Lactoferrin and apoptosis
3.8. Lactoferrin and cancer
3.9. In vivo models
3.10. In vivo models, lactoferrin and cancer
3.11. In vitro models
3.12. 2D models
3.13. 3D models
3.14. Cell Matrix
3.15. 3D models and cancer
3.16. 3D models and breast cancer
4. Conclusions
5. Acknowledgements
6. References

1. ABSTRACT

Lactoferrin (Lf) is a multifunctional protein and an essential element of innate immunity. Cancer is a major killer in today's world accounting for around 13% of all deaths according to the World Health Organisation (W.H.O.). The five most common forms of cancer include lung, colorectal, stomach, liver and breast cancer. Lactoferrin is a natural forming iron-binding glycoprotein with antibacterial, antioxidant and anti-carcinogenic effects. It is produced in exocrine glands and is secreted in many external fluids as a first line of defence. Lactoferrin also has the capacity to induce apoptosis and inhibit proliferation in cancer cells as well as restore white and red blood cell levels after chemotherapy. This review focuses on the therapeutic effect bovine sourced lactoferrin has on various forms of cancer in various models. It also focuses on the benefits of 3D in vitro cell culture. 3D cell culture has vast advantages over 2D models including demonstration of realistic therapeutic results and heightened resistance that 2D models fail to display.