[Frontiers in Bioscience S3, 1421-1431, June 1, 2011]

Cancer immunology and colorectal cancer recurrence

Luca Vannucci1, 2

1Laboratory of Natural Cell Immunity, Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic, 2Laboratory of Tumor Biology, Department of Animal Embryology and Differentiation of Cells and Tissues, Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, v.v.i., Libechov, Czech Republic


1. Abstract
2. Introduction
2. Introduction
3. Approaches for the prevention of colorectal cancer recurrence and related immunological aspects
4. Generalities on cancer immunobiology
5. Inflammation and anticancer immunity
6. Tumor escape and conditions for recurrence
7. Conclusions and perspectives
8. Acknowledgements
9. References


The recurrence of a cancer - local or distant (metastasis) - is manifested by the persistence of cancer cells in the organism after the ablation of the primary lesion, an ineffective anticancer immune response, and by the activity of biological/immunological factors that can stimulate and sustain its development. This review focuses on colorectal carcinoma and discusses some aspects of cancer immunology regarding cancer development and its recurrence. It is addressed also to the clinician to provide new insights helpful for designing better therapeutic strategies and patient's follow up. Therapeutic approaches used during and after surgical treatments, found capable of modulating immunity (differently affecting disease outcome), will also be described.