[Frontiers in Bioscience E4, 1375-1384, January 1, 2012]

Calcium signaling as a regulator of hematopoiesis

Edgar Julian Paredes-Gamero1,2, Christiano M. Vaz Barbosa1, Alice Teixeira Ferreira1

1Universidade Federal de Sao Paulo, Departamento de Biofísica,Rua Botucatu,862, 2 Andar,CEP: 04023-062, Sao Paulo, SP, Brazil, 2Universidade Federal de São Paulo, Departamento de Bioquimica, Rua Tres de Maio, 100, 4 Andar,CEP: 04044-020, Sao Paulo, SP, Brazil


1. Abstract
2. Introduction
2.1. General aspect of Ca2+ signaling
2.2. Hematopoiesis
3. Ca2+ signaling in hematopoietic progenitor cells by cytokines
4. Calcium signaling in hematopoietic progenitor cells by P2 receptors
5. Conclusions
6. Acknowledgements
7. References


Different extracellular signaling molecules that bind to receptors on the cell membrane use calcium ions for signal transduction. Due to the opening of receptor-operated calcium channels, some cytokine receptors and G-protein coupled receptors induce an increase of intracellular calcium concentration upon activation. Calcium ion is a versatile intracellular secondary messenger that control many different cellular functions by changing its cytoplasmic concentration. A specific and complex network of signaling proteins recognizes intracellular calcium alterations to modulate cellular processes. Some reports have previously demonstrated that calcium also regulates hematopoiesis. This review examines the participation of intracellular calcium in hematopoiesis after the stimulus of various myeloid cytokines such as interleukin-3 and granulocyte-macrophage colony-stimulating factor. In addition, the role of adenosine triphosphate and its receptors in inducing calcium increases during hematopoiesis is discussed. Lastly, the participation of this ion in myeloid proliferation and differentiation by cytokines and P2 receptors is also discussed.