[Frontiers in Bioscience 18, 120-132, January 1, 2013]

Nutrition in oncologic patients during antiblastic treatment

Massimiliano Berretta1, Mariagrazia Michieli1, Raffaele Di Francia2, Alessandro Cappellani3, Maurizio Rupolo1, Fabio Galvano4, Rossella Fisichella3, Salvatore Berretta3, Umberto Tirelli1

1Department of Medical Oncology, National Cancer Institute Aviano (Pn) Italy, 2Laboratory of Molecular Hematology, National Cancer Institute, G. Pascale, Naples Italy, 3Department of Surgery, University of Catania, Catania Italy, 4Department of Biological Chemistry, Medical Chemistry, Molecular Biology, University of Catania, Catania Italy


1. Abstract
2. Introduction
3.1. Impact on cancer
3.2. Mechanisms of cancer cachexia
3.3. Medical management
4. General considerations on nutrition and food choices in cancer patients
5. Dietary supplementation and chemotherapy
6. Nutritional recommendations in hematopoietic stem cell transplantation
7. Conclusion
8. Acknowledgments
9. References


Cancer may induce weight loss and cachexia, and cancer treatment may contribute to nutritional impairment. Here, we review the literature on the mechanisms of cancer cachexia and the pharmacological interventions both in use in clinical practice and currently under development. Based on this analysis, several nutritional proposals for cancer patients are suggested and the importance of good nutritional status in candidates for hematopoietic stem cell transplantation is highlighted.