[Frontiers In Bioscience, Scholar, 9, 357-374, June 1, 2017]
Wildlife population management: are contraceptive vaccines a feasible proposition?
Figure 1. Schematic representation of the processes targeted by the contraceptive vaccines meant for wildlife population management. Possible sites have been shown for the action of GnRH- and ZP-based contraceptive vaccines. Antibodies against GnRH will inhibit production of LH and FSH from anterior pituitary thereby leading to inhibition of spermatogenesis in males and ovarian follicular development and ovulation in females. The anti-GnRH antibodies may also act on other extra-pituitary sites such as placenta, testis, ovary, heart, prostate, urinary bladder etc. Antibodies against ZP curtail fertility by either inhibiting folliculogenesis or fertilization or both.