Human Cluster of differentiation (CD) Cellular Antigens

CD
Name

Other
Names

Molecular weight

Structure

Distribution

Function

CD1a

T6

49kD

IgSF, MHC-like

cortical thymocytes, Langerhans cells, DC

antigen presentation, with b2m

CD1b

T6

45kD

IgSF, MHC-like

cortical thymocytes, Langerhans cells, DC

antigen presentation, with b2m

CD1c

T6

43kD

IgSF, MHC-like

cortical thymocytes, Langerhans cells, DC, B subset

antigen presentation, with b2m

CD1d

 

49kD

IgSF, MHC-like

intestinal epith, B subset, monolow, DC

antigen presentation, with b2m

CD1e

 

28kD

IgSF, MHC-like

DC

antigen presentation, with b2m

CD2

T11, LFA-2, SRBC-R

50kD

IgSF

thymocytes, T, NK

CD58 ligand, adhesion, T cell activation

CD2R

T11-3

50kD

IgSF

Tact

activation-dependent form of CD2

CD3 gamma, CD3 delta

T3

 

IgSF

T, thymocyte subset

with TCR, TCR surface expression / signal transduction

CD3 epsilon

T3

20kD

IgSF

T, thymocyte subset

with TCR, TCR surface expression / signal transduction

 

 

 

 

 

 

 

 

 

 

 

 

CD4

T4

55kD

IgSF

thymocyte subset, T subset, mono, mac

MHC class II coreceptor, HIV receptor, T cell differentiation / activation

 

 

 

 

 

 

CD5

T1, Tp67

67kD

Scavenger R SF

thymocytes, T, B subset, B-CLL

CD72 receptor, TCR or BCR signaling, T-B interaction

CD6

T12

100-130kD

Scavenger R SF

thymocytes, T, B subset

CD166 receptor, T cell differentiation / costimulation

CD7

 

40kD

IgSF

hematopoietic progenitors, thymocytes, T, NK

T costimulation

CD8a

T8, Leu-2

32-34kD

IgSF

thymocyte subset, T subset, NK

MHC class I coreceptor, receptor for some mutated HIV-1, T cell differentiation / activation

 

 

 

 

 

 

 

 

 

 

 

 

CD8b

 

30-32kD

IgSF

thymocyte subset, T subset

 

CD9

p24, MRP-1

22-27kD

TM4SF

pre-B, eosinophils, basophils, platelets, Tact

cellular adhesion and migration

CD10

CALLA, NEP, gp100

100kD

type II TM

B precursors, T precursors, neutrophils

zinc-binding metalloproteinase, B cell development

CD11a

LFA-1, integrin alphaL

180kD

Integrin family

lymph, gran, mono, mac

CD11a / CD18 receptor for ICAM-1, -2,-3, intercellular adhesion, T costimulation

CD11b

Mac-1, integrin alphaM

170kD

Integrin family

myeloid cells, NK

binds CD54, ECM, iC3b

 

 

 

 

 

 

CD11c

p150, 95, CR4, integrin alphaX

150kD

Integrin family

DC, myeloid cells, NK, B, T subset

binds CD54, fibrinogen and iC3b

CD12

 

90-120kD

 

mono, gran, platelets

 

CD13

Aminopeptidase N, APN

150-170kD

type II TM

myeloid cells

zinc-binding metalloproteinase, antigen processing, receptor for corona virus strains

CD14

LPS-R

53-55kD

GPI-linked

mono, mac, Langerhans cells, granlow

receptor for LPS/LBP, LPS recognition

CD15

Lewis-x, Lex

 

CHO

neutrophils, eosinophils, mono

adhesion

CD15s

Sialyl Lewis X

 

CHO

neutrophils, eosinophils, mono, memory helper T, Tact and B, NK, HEV

CD62L and CD62P ligand, adhesion

CD15u

Sulfated Lewis X

 

CHO

myeloid subset

adhesion

CD16a

FcgammaRIIIA

50-65kD

IgSF

neutrophils, mac, NK

component of low affinity Fc receptor, phagocytosis and ADCC

CD16b

FcgammaRIIIB

48kD

IgSF

neutrophils

component of low affinity Fc receptor, phagocytosis and ADCC

CD17

 

 

 

neutrophils, mono, platelets

lactosyl ceramide

CD18

Integrin b2

95kD

Integrin family

broad, all leukocytes

with CD11a, b & c, adhesion

CD19

B4

95kD

IgSF

B, FDC

complex with CD21 and CD81, BCR coreceptor, B cell activation / differentiation

CD20

B1, Bp35

33-37kD

TM4SF

B, T subset

B cell activation

CD21

C3DR, CR2, EBV-R

145,110kD

CCRSF

B, FDC, T subset

complement C3d and EBV receptor, complex with CD19 and CD81, BCR coreceptor

CD22

BL-CAM, Siglec-2

150kD

IgSF, sialoadhesins

B

adhesion, B-mono, B-T interactions

CD23

FcepsilonRII

45kD

C-type lectin

B, activated mac, eosinophils, FDC, platelets

CD19-CD21-CD81 receptor, IgE low affinity receptor, signal transduction

CD24

BA-1

35-45kD

GPI-linked

thymocytes, erythrocytes, peripheral lymph, myeloid

binds P-selectin

CD25

Tac, p55

55kD

type I TM

Tact, Bact, lymph progenitors

IL-2Ralpha, with IL-2Rb and gamma to form high affinity complex

CD26

DPP IV

110kD

type II TM

thymocyte subset, Tact, soluble form

dipeptidyl peptidase, T costimulation, HIV entry

CD27

T14

50-55kD

TNFRSF

medullary thymocytes, T, B subset, NK subset

CD70 receptor, T costimulation

 

 

 

 

 

 

CD28

Tp44, T44

44kD

IgSF

most T, thymocytes, plasma cells

CD80, CD86 receptor, T costimulation

 

 

 

 

 

 

CD29

Integrin b1

130kD

Integrin family

lymph, mono, granlow, platelets, mast cells, fibroblasts, endoth

with CD49a (VLA-1) receptor for VCAM-1, MAdCAM-1 and ECM

CD30

Ki-1

105-120kD

TNFRSF

Bact, T and NK , Reed-Sternberg cells, anaplastic large cell lymphoma

CD153 receptor, lymph proliferation / apoptosis

CD31

PECAM-1

130-140kD

IgSF

mono, platelets, gran, endoth, lymph subset

CD38 receptor, adhesion

CD32

FcgammaRII

40kD

IgSF

mono, gran, B, platelets

low affinity Fc receptor for aggregated Ig and immune complexes

CD33

p67, Siglec-3

67kD

IgSF, sialoadhesins

myeloid progenitors, mono, gran, DC, mast cells, Tact

adhesion

 

 

 

 

 

 

CD34

 

105-120kD

Sialomucin, type I TM

hematopoietic precursors, capillary endoth, embryonic fibroblasts

stem cell marker, adhesion, CD62L receptor

CD35

CR1

250kD

CCRSF

erythrocytes, B, mono, neutrophils, eosinophils, FDC, T subset

complement receptor 1, binds C3b and C4b, adhesion, phagocytosis

CD36

GPIV

88kD

 

platelets, mono, mac, endoth, early erythrocytes

ECM receptor, adhesion, phagocytosis

CD37

 

40-52kD

TM4SF

B, Tlow, granlow

signal transduction

CD38

T10

45kD

 

variable levels on majority of hematopoietic cells, high expression on plasma cells, B and Tact

ecto-ADP-ribosyl cyclase, cell activation

CD39

 

78kD

NK, mac, Langerhans cells, DC, Bact

B cell adhesion, protects activated cells from lysis, ecto-apyrase

 

CD40

 

48kD

TNFRSF

B, mono, mac, FDC, endoth, T subset

CD154 receptor, B differentiation / costimulation, isotype-switching, rescues B cells from apoptosis

CD41

gpIIb

125/22kD

Integrin family

platelets, megakaryocytes

with CD61 forms GPIIb, binds fibrinogen, fibronectin, vWF, thrombospondin, platelet activation and aggregation

 

 

 

 

 

 

CD42a

GPIX

22kD

LRRF

platelets, megakaryocytes

complex with CD42b, c and d, receptor for vWF and thrombin, platelet adhesion to subendothelial matrices

CD42b

GPIba

145kD

LRRF

platelets, megakaryocytes

complex with CD42a, c and d, binds to vWF and thrombin, platelet adhesion / activation

CD42c

GPIbb

24kD

LRRF

platelets, megakaryocytes

complex with CD42a, b, d

CD42d

GPV

82kD

LRRF

platelets, megakaryocytes

complex with CD42a-c

CD43

Leukosialin, sialophorin

115-135kD

Sialomucin, type I TM

leukocytes, except resting B, plateletslow

inhibition of T cell interaction, CD54R, adhesion

CD44

H-CAM, Pgp-1

80-95kD

hyaladherin family

hematopoietic and non-hematopoietic cells, except platelets, hepatocytes, testis

binds hyaluronic acid, adhesion

CD44R

CD44v

 

 

CD44 variants heterogeneous expression, constitutively on epith, mono, upregulated on activated leukocytes

adhesion, metastasis

CD45

LCA, T200, B220

180-240kD

 

hematopoietic cells, multiple isoforms from alternative splicing

tyrosine phosphatase, enhanced TCR & BCR signals

 

 

 

 

 

 

CD45RA

 

205-220kD

 

B, T subset(naive), mono

exon A isoforms of CD45

 

 

 

 

 

 

CD45RB

 

190-220kD

 

T subset, B, mono, mac, gran

exon B isoforms of CD45

CD45RO

 

180kD

 

Tact, memory T, B subset, mono, mac, gran

isoform of CD45 lacking A, B, C exons

CD46

MCP

56/66kD

CCRSF

nucleated cells

membrane cofactor protein, binds C3b & C4b allowing degradation by Factor I, measles virus receptor

CD47

IAP

47-52kD

IgSF

hematopoietic cells, epith, endoth, fibroblasts, other tissues

leukocyte adhesion, migration, activation

CD47R

 

 

 

New designation for CDw149, similar distribution as CD47 but dimmer

 

CD48

Blast-1

45kD

IgSF

broad, all leukocytes

cell adhesion

CD49a

VLA-1

210kD

Integrin family

Tact, mono

integrin alpha1, adhesion, CD49a/CD29 binds collagen and laminin

CD49b

VLA-2

165kD

Integrin family

B, mono, platelets, Tact, megakaryocytes

integrin alpha2, adhesion, CD49b / CD29 binds collagen and laminin

CD49c

VLA-3

125kD

Integrin family

B and Tlow, most adhesive cell lines

integrin alpha3, adhesion, CD49c/CD29 binds laminin, fibronectin and collagen

CD49d

VLA-4

150kD

Integrin family

T, B, NK, thymocytes, mono, eosinophils, mast, DC

integrin alpha4, adhesion, CD49d/CD29 binds fibronectin, VCAM-1 & MAdCAM-1

CD49e

VLA-5

135, 25kD

Integrin family

thymocytes, T, mono, platelets, early and Bact

integrin alpha5, adhesion, CD49e/CD29 binds fibronectin

CD49f

VLA-6

125kD

Integrin family

memory T, thymocytes, mono, platelets, megakaryocytes, epith

integrin alpha6, adhesion, CD49f / CD29 binds laminin

CD50

ICAM-3

110-120kD

IgSF

hematopoietic, endoth, epidermal Langerhans cells

adhesion, costimulation

CD51

Vitronectin receptor

125, 24kD

Integrin family

plateletslow, endoth, osteoblasts, melanomas

integrin alphav, adhesion, CD51 / CD61 binds vitronectin, vWF, fibrinogen and thrombospondin

CD52

CAMPATH-1

21-28kD

 

thymocytes, T, B (not plasma cells), mono, mac

 

CD53

 

35-42kD

TM4SF

leukocytes, DC, osteoblasts, osteoclasts

signal transduction

CD54

ICAM-1

90-110kD

IgSF

endoth, mono, lymph (high upon activation)

receptor for CD11a / CD18 (LFA-1), CD11b/CD18 (Mac-1) and rhinovirus

CD55

DAF

60-70kD

GPI-linked

hematopoietic, endoth

binds C3b, complement regulation

CD56

NCAM

175-185kD

IgSF

NK, T subset, neurons, some large granular lymphocyte leukemias, myeloid leukemias

adhesion

CD57

HNK-1, Leu-7

110kD

 

NK subset, T subset

 

CD58

LFA-3

55-70kD

IgSF

hematopoietic, non-hematopoietic cells

CD2 receptor, adhesion

CD59

Protectin, MAC- inhibitor

19kD

GPI-linked

hematopoietic, non-hematopoietic cells

binds complement C8 and C9, blocks assembly of membrane attack complex

CD60a

GD3

 

CHO

T subset, platelets, thymic epith, astrocytes

costimulation

CD60b

9-O-sialyl GD3

 

CHO

T subset, Bact

 

CD60c

7-O-sialyl GD3

 

CHO

T subset

 

CD61

GPIIIa

105kD

Integrin family

platelets, megakaryocytes, mac, endoth

integrin b3, adhesion, CD41/CD61 or CD51 / CD61 mediate adhesion to ECM

CD62E

E-selectin, ELAM-1

97,107-115kD

Selectin family

endoth

binds CD15s, cell rolling, metastasis

CD62L

L-selectin, LECAM-1

74, 95kD

Selectin family

B, naïve and memory T, mono, gran, NK, thymocytes

CD34, GlyCAM, and MAdCAM-1 receptor, leukocyte homing, tethering, rolling

CD62P

P-selectin, PADGEM

140kD

Selectin family

activated platelets, endoth

CD162, CD15s receptor, adhesion, neutrophil rolling, platelet-neutrophil and platelet-mono interactions

CD63

LIMP, LAMP-3

53kD

TM4SF

activated platelets, mono, mac

lysosomal membrane protein, moves to cell surface after activation

CD64

FcgammaRI

72kD

IgSF

mono, mac, DC, Interferon or G-CSF activated gran

high affinity receptor for IgG, phagocytosis and ADCC

CD65

 

 

 

gran, mono subset, myeloid leukemias

 

CD65s

VIM2

 

 

gran, mono, myeloid leukemias

phagocytosis

CD66a

BGP-1, NCA-160

160-180kD

IgSF, CEA family

neutrophils, epith

cell adhesion

CD66b

CD67, CGM6

95-100kD

IgSF, CEA family

gran

cell adhesion, neutrophil activation

CD66c

NCA

90kD

IgSF, CEA family

neutrophils, colon carcinoma

cell adhesion

CD66d

CGM1

35kD

IgSF, CEA family

neutrophils

 

CD66e

CEA

180-200kD

IgSF, CEA family

colon epith, colon cancer

cell adhesion

CD66f

PSG, Sp-1

54-72kD

IgSF, CEA family

pregnancy specific glycoprotein, placental syncytiotrophoblasts, fetal liver

immune regulation, protects fetus from maternal immune system

CD68

Macrosialin, gp110

110kD

Sialomucin

intracellularly in mono, mac, neutrophils, basophils, large lymph, mast cells, DC, myeloid progenitors, liver

 

CD69

AIM

28, 32kD

C-type lectin

Tact, B, NK and gran, thymocytes, platelets, Langerhans cells

signal transduction

CD70

Ki-24

50, 70, 90, 160kD

TNFSF

Bact and Tact

CD27 ligand, T and B cell costimulation

CD71

T9

95kD

 

proliferating cells, reticulocytes, erythroid precursors

transferrin receptor, iron uptake

 

 

 

 

 

 

CD72

Lyb-2

42kD

C-type lectin

B, FDC

CD5, CD100 receptor, B proliferation

CD73

 

69kD

GPI-linked

B subset, T subset, FDC, epith

ecto-5’-nucleotidase, nucleoside uptake, T costimulation, lymph adhesion

CD74

Ii, invariant chain

33, 35, 41, 43kD

 

B, mac, mono, Langerhans cells, DC, Tact

MHC class II traffic and function

CD75

 

 

CHO Sialoglycan family

B subset, epith

lactosamines

CD75s

 

 

CHO Sialoglycan family

B subset, T subset

alpha-2,6-sialylated lactosamines (previously CDw75 and CDw76)

CD77

Gb3, Pk blood group

 

 

germinal center B, Burkitt’s lymphomashigh, follicular lymphomaslow

apoptosis

CD79a

Iga

33, 45kD

IgSF

B

component of BCR, BCR surface expression and signal transduction

CD79b

Igb

37kD

IgSF

B

component of BCR, BCR surface expression and signal transduction

CD80

B7, B7-1, BB1

60kD

IgSF

Bact and Tact, mac, DC

binds to CD28, CD152, T costimulation

CD81

TAPA-1

26kD

TM4SF

T, B, NK, thymocytes, DC, endoth, fibroblast, neuroblastomas, melanomas

complex with CD19 & CD21, signaling, T costimulation

CD82

R2

50-53kD

TM4SF

leukocytes

signal transduction

CD83

HB15

43kD

IgSF

Bact and Tact, DC, Langerhans cells

 

CDw84

 

73kD

 

mono, platelets, B, T subset, mac subset

 

CD85

 

110kD

IgSF, ILT/LIR family

DC, mono, B, NK, T subset

inhibition of NK, T cell cytolytic function

CD86

B70, B7-2

80kD

IgSF

mono, DC, Bact and Tact

binds to CD28, CD152, T costimulation

CD87

UPA-R

39-66kD

GPI-linked

gran, mono, NK, Tact, endoth, fibroblasts

urokinase plasminogen activator receptor, inflammatory cell invasion, metastasis

CD88

C5aR

40kD

TM7SF

gran, mono, DC

C5a receptor, granulocyte activation

CD89

FcalphaR

55-75kD

IgSF

mono, mac, gran, neutrophils, B subset, T subset

IgA receptor, phagocytosis, degranulation, respiratory burst

CD90

Thy-1

25-35kD

IgSF, GPI-linked

CD34+ hematopoietic subset, neurons

hematopoietic stem cell and neuron differentiation

CD91

 

600kD

LDLR family

mono, mac, neurons, fibroblasts

receptor for alpha-2-macroglobulin

CD92

 

70kD

 

neutrophils, mono, platelets, endoth, fibroblasts

 

CD93

 

120kD

 

neutrophils, mono, endoth

 

CD94

KP43

43kD

C-type lectin

NK, T subset

complex with NKG2, inhibits NK function

CD95

Apo-1, Fas

45kD

TNFRSF

lymph (high upon activation), mono, neutrophils

FasL (CD178) receptor, apoptosis

 

 

 

 

 

 

CD96

TACTILE

160kD

IgSF

NK, Tact

adhesion of activated T and NK

CD97

 

74, 80, 90kD

TM7SF

Bact and Tact, mono, gran

 

CD98

4F2

80, 40kD

 

T, B, NK, gran, all human cell lines

cellular activation

CD99

MIC2, E2

32kD

 

leukocytes

T cell activation, adhesion

CD99R

E2

32kD

 

T, NK, myeloid cells

isoform of CD99

CD100

 

150kD

 

hematopoietic cells except immature bone marrow cells, RBC and platelets

cell adhesion, cellular activation

CD101

V7, p126

120kD

IgSF

mono, gran, DC, Tact

T cell activation

CD102

ICAM-2

55-65kD

IgSF

lymph, mono, platelets, endoth

binds CD11a / CD18, costimulation

CD103

HML-1, alpha6, integrin alphaE

150, 25kD

Integrin family

intraepithelial lymph, lymph subset, activated lymph

with integrin b7, binds E-cadherin, lymph homing/retention

CD104

b4 integrin

220kD

Integrin family

epith, Schwann cells, keratinocytes, some tumor cells

with integrin alpha6 (CD49f), cell adhesion, differentiation, metastasis

CD105

Endoglin

95kD

homodimer

endoth, bone marrow subset, activated mac

cellular response to TGF-b1

CD106

VCAM-1

110kD

IgSF

activated endoth, FDC

VLA-4 (CD49d / CD29) receptor, leukocyte adhesion, migration, costimulation

CD107a

LAMP-1

110kD

 

activated platelets, T, endoth, metastatic tumors

a lysosomal membrane protein

CD107b

LAMP-2

120kD

 

activated platelets, T, endoth, metastatic tumors

a lysosomal membrane protein

CD108

 

80kD

 

erythrocytes, lymphoblasts, resting lymphlow

 

CD109

 

170kD

 

Tact and platelets, CD34+ subset, endoth

 

CD110

MPL, TPO-R

82-84kD

CRSF

megakaryocytes, platelets, some CD34+ stem cellslow

thrombopoietin receptor, megakaryocyte progenitor cell growth / differentiation

CD111

PRR1, Nectin-1

64-72kD

IgSF

stem cell subset, mac, neutrophils

 

CD112

PRR2, Nectin-2

64-72kD

IgSF

mono, neutrophils, CD34+ subset, megakaryocytes, endoth, epith

intercellular adhesion

CD113

PVRL3, Nectin3

83kD

IgSF

testis, placenta

adhesion molecule that interacts with afadin

CD114

G-CSFR

95, 139kD

CRSF

myeloid progenitors, endoth

myeloid differentiation / proliferation

CD115

M-CSFR, c-fms

150kD

IgSF, RTK family

mono, mac, monocytic progenitors

CSF-1R, monocytic differentiation / proliferation

CD116

GM-CSFRalpha

70-85kD

CRSF

mono, gran, DC, endoth

with common b, myeloid differentiation / proliferation

CD117

c-kit, SCFR

145kD

IgSF, RTK family

hematopoietic progenitors, mast cells

SCF receptor, hematopoietic progenitor development / differentiation

CD118

LIFR, gp190

190kD

Type I CRSF & secreted forms

epithelial cells in adult and embryo

membrane-bound involved in signal transduction, soluble form inhibits activity of LIF

CD119

IFNgammaR

90-100kD

 

mac, mono, B, T, NK, neutrophils, endoth

IFN-gamma Ralpha, with IFN-gamma AF-1, host defense

CD120a

TNFR-I

50-60kD

TNFRSF

hematopoietic, non-hematopoietic cells

receptor for both TNF-alpha and TNF-b

CD120b

TNFR-II

75-85kD

TNFRSF

hematopoietic, non-hematopoietic cells

receptor for both TNF-alpha and TNF-b

CD121a

IL-1R type I

80kD

IgSF

dimly expressed on many cells

binds IL-1alpha and IL-1b, IL-1 signaling

CD121b

IL-1R, type II

60-70kD

IgSF

B, mac, mono, T subset

binds IL-1alpha and IL-1b, negative signals

CD122

IL-2Rb

75kD

CRSF

NK, T, B, mono

IL-2Rb and IL-15Rb, signal transduction

CD123

IL-3R

70kD

CRSF

lymph subset, basophils, hematopoietic progenitors, mac, DC, megakaryocytes

IL-3Ralpha, with CDw131

CD124

IL-4R

140kD

CRSF

lymphlow, mono, hematopoietic precursors, .broblast, epith

IL-4Ralpha, with CD132 or IL-13Ralpha, T cell growth / differentiation

CD125

IL-5R

60kD

CRSF

eosinophils, basophils

IL-5Ralpha, with CDw131

CD126

IL-6R

80kD

IgSF, CRSF

Bact and plasma cells, most leukocyteslow, fibroblasts

IL-6Ralpha, with CD130

CD127

IL-7R

65-75kD

CRSF

T, pro-B

IL-7Ralpha, with CD132, B and T cell development

CD128

see CD181 & CD182

 

 

 

 

CD130

IL-6Rb, gp130

130kD

CRSF

Bact and plasma cells, most leukocyteslow, endoth

IL-6Rb, IL-6, IL-11, LIF, CNF signals

CD131

IL-3R common b

95-120kD

CRSF

mono, gran, early B

with alpha subunits of IL-3R, IL-5R, and GM-CSFR, signal transduction

CD132

Common gamma

64kD

CRSF

T, B, NK, mono, gran

subunit of IL-2R, IL-4R, IL-7R, IL-9R, and IL-15R, signal transduction

CD133

AC133, prominin-like 1

120kD

TM5SF

hematopoietic stem cell subset, epith, endoth

 

CD134

OX-40

48-50kD

TNFRSF

Tact

T cell activation, differentiation, apoptosis

CD135

Flt3/Flk2

130-150kD

RTK family

myelomonocytic, primitive B progenitors

tyrosine kinase, binds FLT3 ligand, early lymph development

CD136

MSP-R, RON

180kD

RTK family

epith, CNS, PNS, hematopoietic subset

migration, morphological change and proliferation of different target cells

CD137

4-1BB

30kD

TNFRSF

Tact

T costimulation

CD138

Syndecan-1

80-150kD

Syndecan family

plasma cells, pre-B, basolateral surface of epith, meurons

receptor for ECM, cell morphology

CD139

 

228kD

 

B, mono, gran, erythrocyteslow

 

CD140a

PDGFRalpha

180kD

RTK family

fibroblasts, smooth muscle & glial cells, chondrocytes

binds PDGF A and B

CD140b

PDGFRb

180kD

RTK family

fibroblasts, smooth muscle & glial cells, chondrocytes

binds PDGF B

CD141

Thrombomodulin

100kD

C-type lectin

mono, neutrophils, endoth, smooth muscle cells

initiation of protein C anticoagulant signal

CD142

Tissue Factor

45kD

 

mono, endoth, keratinocytes, epith

binds clotting factor VIIa, initiator of clotting

CD143

ACE

170kD

 

endoth, epith, neurons, fibroblasts, activated mac

angiotensin converting enzyme, angiotensin II & bradykinin metabolism

CD144

VE-Cadherin, Cadherin-5

130kD

Cadherin family

endoth

adhesion, cell-cell interaction

CD145

 

110, 90kD

 

endoth, some stromal cells

 

CD146

MUC18, S-endo

113-118kD

IgSF

endoth, melanomas, FDC, Tact

adhesion

CD147

Neurothelin, basoglin

 

IgSF

leukocytes, erythrocytes, platelets, endoth

adhesion

CD148

HPTP-eta

240-260kD

 

gran, mono, DC, T (high upon activation)

tyrosine phosphatase R Type III

CD150

SLAM

75-95kD

IgSF

T subset (high upon activation), B, DC, endoth

costimulation, proliferation, Ig production, measles virus receptor

CD151

PETA-3

32kD

 

endoth, megakaryocytes, platelets, epith

cell adhesion

CD152

CTLA-4

33kD

IgSF

Tact and B

CD80 and CD86 receptor, negative regulation of T cell costimulation

 

 

 

 

 

 

CD153

CD30L

40kD

TNFSF

neutrophils, B, Tact and mac

CD30 ligand, T costimulation

CD154

CD40L, gp39, TRAP

32-39kD

TNFSF

Tact

CD40 ligand, B and DC costimulation

CD155

PVR

80-90kD

IgSF

mono, mac, CD34+ thymocytes

Polio virus receptor (PVR)

CD156a

ADAM8

69kD

 

neutrophils, mono

leukocyte extravasation

CD156b

TACE / ADAM 17

100kD

 

broad

cleaves membrane proteins (TNF, TGFalpha) to generate soluble forms

CD156c

ADAM10

98kD

Peptidase M12B family

lymphoid organs, peripheral blood leukocyte, cartilage, chondrocytes and fetal liver

proteolytic cleavage of cell-surface molecules including Notch, TNF-alpha, APP and ephrin-A2

CD157

BST-1

42-45kD

 

gran, mono, B progenitors, endoth

ADP-ribosyl-cyclic ADP-ribose hydrolase activities, pre-B cell growth

CD158a

p58.1

50-58kD

IgSF, KIR family

NK subset, T subset

inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor

CD158b

p58.2

50-58kD

IgSF, KIR family

NK subset, T subset

inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor

CD159a

NKG2A

43kD

 

T subset, NK

with CD94, NK cell receptor

CD159c

NKG2C

40kD

Type II C-Type Lectin

NK

with MHC class I HLA-E molecules, forms heterodimer with CD94

CD160

BY55

27kD

IgSF

NK subset, T subset

costimulation

CD161

NKR-P1A

40kD

C-type lectin

T subset, NK

NK cell-mediated cytotoxicity

CD162

PSGL-1

120kD

Mucin family

mono, gran, most lymph

CD62P, CD62L ligand, adhesion, rolling

CD162R

PEN-5

 

CHO

NK subset

 

CD163

130kD

 

Scavenger receptor SF

mono, mac

 

CD164

MGC-24

80kD

epith, mono, lymphlow, bone marrow stromal cells, CD34+ erythroid progenitors

hematopoietic progenitor cell-stromal cell interaction

 

CD165

AD2, gp37

42kD

lymph subset, mono, immature thymocytes, platelets

adhesion, thymocyte-thymic epith interaction

 

CD166

ALCAM

105kD

IgSF

neurons, mono, epith, fibroblasts, Tact

CD6 ligand, adhesion

CD167a

DDR1

120kD

RTK family

epith, myoblasts

tyrosine kinase, adhesion to collagen

CD168

RHAMM

84-88kD

 

mono, T subset, thymocyte subset, intracellularly in breast cancer cells

adhesion, tumor migration, metastasis

CD169

sialoadhesin, Siglec-1

185kD

IgSF, sialoadhesins

tissue mac subset

adhesion, cell-cell and cell-matrix interactions, binds CD227 on breast cancer cells and CD43 on T cells

CD170

Siglec-5, CD33-like2

140kD

IgSF, sialoadhesins

Mac subset, neutrophils

adhesion

CD171

L1

200-210kD

IgSF

CNS, PNS, glial cells, mono, T subset, B, DC, several human tumor cells

kidney morphogenesis, lymph node architecture, T costimulation, neurohistogenesis, homotypic interaction, binds CD9, CD24, CD56, CD142, CD166, integrins

CD172a

SIRPgamma

110kD

 

mono, T subset, stem cells

adhesion, complex with CD47

CD172b

SIRPb, SIRB1

50kD

IgSF

mono and DC

negative regulation of RTK-coupled signaling

CD172g

SIRPgamma, SIRPB2

45-50kD

IgSF, ASV

mRNA: liver and at lower levels in many tissues

binds CD47

CD173

Blood group H type 2

 

CHO

erythrocytes, stem cell subset, platelets

 

CD174

Lewis Y

 

CHO

stem cells subset, epith

 

CD175

Tn

 

CHO

stem cells subset

 

CD175s

Sialyl-Tn

 

CHO

erythroblasts

 

CD176

Thomson Friedrenreich Ag

 

CHO

stem cell subset

 

CD177

NB1

56-62kD

 

neutrophil subset

 

CD178

FasL, CD95L

38-42kD

TNFSF

Tact, testis

CD95 ligand, apoptosis, immune privilege, soluble form in serum

CD179a

V pre B

16-18kD

IgSF

Pro- and Pre-B

B cell differentiation / signaling, with IgM

CD179b

Lambda 5

22kD

IgSF

Pro- and Pre-B

B cell differentiation / signaling, with IgM

CD180

RP-105

95-105kD

LRRF, TLR family

B subset, mono, DC

B cell activation, LPS signaling, with MD-1

CD181

CXCR1, IL-8RA

39kD

GPCR1 family

neutrophils, basophils, NK, T subset, mono

binding of IL-8 induces chemotaxis of neutrophils

CD182

CXCR2, IL-8RB

40kD

GPCR1 family

neutrophils, basophils, NK, T subset, mono

binding of IL-8 induces chemotaxis of neutrophils

CD183

CXCR3

40kD

TM7SF

eosinophils, Tact and NK, GM-CSF activated CD34+ progenitors

IP-10 , Mig and I-TAC receptor, T cell recruitment to inflammatory sites, enhancement of Th1 response

CD184

CXCR4, fusin

45kD

TM7SF

B, DC, T subset, mono, endoth

SDF-1 receptor, X4 HIV-1 coreceptor

CD185

CXCR5, BLR1

45kD

GPCR1 family

mature B and Burkitt Lymphoma cells

with chemokine BLC, possible regulatory function in Burkitt Lymphomagenesis and/or B differentiation, activation of mature B

CD186

CXCR6, BONZO

40kD

GPCR1 family

Tact

receptor for CXCL16 and coreceptor for SIV, strains of HIV-2 and m-tropic HIV-1

CD191

CCR1, MIP-1alphaR, RANTES-R

39kD

GPCR1 family

T, mono, stem cell subset

binds C-C type chemokines and transduces signal by increasing intracellular calcium ion levels

CD192

CCR2, MCP-1-R

40kD

GPCR1 family

activated NK and mononuclear phagocytes, T subset, B, endoth

binds MCP-1, MCP-3 & MCP-4, alternative coreceptor with CD4 for HIV-1 infection

CD193

CCR3, CKR3

45kD

GPCR1 family

eosinophils, lower expression in neutrophils and mono, T subset

binds eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES & MIP-1delta, alternative coreceptor with CD4 for HIV-1 infectiongg

CD195

CCR5

45kD

 

mono, T subset

MIP-1alpha, MIP-1b and RANTES receptor, R5 HIV-1 coreceptor

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CD196

CCR6, LARC receptor, DRY6

45kD

GPCR1 family

T subset, B, DC subset

binds MIP-3alpha/LARC

CD197

CCR7

45kD

 

T subset, DC Subset

6Ckine and MIP-2b receptor

CD198

CCR8, GPRCY6, TER1

50kD

GPCR1 family

T, high expression in Th2, NK, mono

allergic inflammation, alternative coreceptor with CD4 for HIV-1 infection

CD199

CCR9, GPR-9-6

43kD

GPCR1 family

subset of memory T, lamina propria mononuclear cells

binds SCYA25/TECK, alternative coreceptor with CD4 for HIV-1 infection

CD200

OX-2

45-50kD

 

thymocytes, endoth, B, Tact

inhibition of immune response

CD201

EPC-R

50kD

 

endoth subset

activated protein C receptor

CD202b

Tie2, Tek

150kD

RTK family

stem cells, endoth

angiopoietin-1 receptor

CD203c

NPP3 / PDNP3, ENpp1, PD-1b

130-150kD

type II TM

basophils, mast cells, glioma cells, megakaryocytes

ectoenzyme, binding to and clearance of extracellular nucleotides

CD204

Macrophage scavenger-R

220kD

 

mac

endocytosis of macromolecules

CD205

DEC-205

205kD

 

DC, thymic epith

DC, thymic epith

CD206

macrophage mannose-R

180kD

 

DC subset, mac, mono

phagocytosis and pinocytosis of mannose containing molecules

CD207

Langerin

40kD

 

Langerhans cells

endocytic receptor

CD208

DC-LAMP

70-90kD

 

DCact, interdigitating DC

 

CD209

DC-SIGN

44kD

 

DC subset

ICAM-3 receptor, HIV-1 binding protein

 

 

 

 

 

 

CD210

IL-10-R

90-110kD

 

T, B, NK, mono, mac

IL-10 receptor, signal transduction

CD212

IL-12-R b1

100kD

 

Tact and NK

binds IL-12 with high affinity, associates with IL-12 receptor b2

CD213a1

IL-13-R alpha1

65kD

 

B, mono, fibroblasts, endoth

binds IL-13 with low affinity, with CD124

CD213a2

IL-13-R alpha2

65kD

 

B, mono

binds IL-13 with high affinity

CD217

IL-17-R

120kD

 

broad

IL-17 receptor

CD218a

IL-18Ralpha, IL-1Rrp

70kD

IL-1R family

T, NK, DCs

binds IL-18, activation of NF-kappaB

CD218b

IL-18Rb, IL18RAP

70kD

IL-1R family

T, NK and DCs

heterodimeric receptor with IL-18Ralpha to enhance IL-18 binding

CD220

Insulin-R

140, 70kD

 

broad

insulin receptor

CD221

IGF-1 R

140, 70kD

 

broad

binds IGF with high affinity, signaling, cell proliferation/ differentiation

CD222

IGF-II R, mannose-6 phosphate-R

250kD

Type I TM

broad, 90-95% intracellular

adhesion, tumor growth, a receptor for TGFb-LAP, plasminogen, proliferin, truncated form (220kD) found in serum

CD223

LAG-3

70kD

IgSF

Tact and NK

an MHC class II ligand

CD224

GGT

27, 68kD

 

leukocytes, stem cells

 

CD225

Leu-13

17kD

 

broad

 

CD226

DNAM-1, PTA-1, TLiSA1

65kD

IgSF

T, NK, mono, platelets, activated HUVEC

activation of cell-mediated cytotoxicity, soluble form (50kD) found in normal serum

CD227

MUC1, EMA

300kD

Mucin family, type I TM

epith, stem cell subset, FDC, mono, B subset, some myelomas

adhesion, signaling, binds CD169, CD54, & selectins

CD228

Melanotransferrin

80-95kD

 

stem cells, melanomas

 

CD229

Ly-9

95, 110kD

IgSF

T, B

adhesion

CD230

Prion protein

35kD

broad

 

 

CD231

TALLA-1, A15

30-45kD

TM4SF

T leukemias, neuroblastomas, brain neurons

marker for T cell acute lymphoblastic leukemia

CD232

VESP-R

200kD

 

broad

 

CD233

Band 3, SLC4A1

90kD

Anion exchanger family

erythrocytes

anion exchanger pump, transport of CO2, linking red cell membrane to cytoskeleton

CD234

Duffy, DARC

35-45kD

 

erythrocytes

Duffy antigen chemokine receptor

CD235a

Glycophorin A

36kD

 

erythrocytes

 

CD235ab

Glycophorin A/B

20kD

 

erythrocytes

 

CD235b

Glycophorin B

20kD

 

erythrocytes

 

CD236

Glycophorin C/D

32, 23kD

 

erythrocytes, stem cell subset

 

CD236R

Glycophorin C

32kD

 

erythrocytes, stem cell subset

 

CD238

Kell

93kD

 

erythrocytes, stem cell subset

 

CD239

B-CAM

78-85kD

 

erythrocytes, stem cell subset

 

CD240CE

Rh30CE

30-32kD

 

erythrocytes

 

CD240D

Rh30D

30-32kD

TM12SF

erythrocytes

 

CD241

RhAg, Rh50

50kD

TM12SF

erythrocytes

complex with CD47, LW, glycophorin B

CD242

ICAM-4

42kD

IgSF

erythrocytes

adhesion, Landsteiner-Wiener blood group

CD243

MDR-1, p170, P-gp

180kD

 

stem cells, small intestine, kidneystem cells, small intestine, kidney

ion pump

CD244

2B4

70kD

type II TM

T subset, mono, basophils, NK

NK activation, CD48 ligand

 

 

 

 

 

 

CD245

p220/240

220-240kD

 

T subset

 

CD246

ALK, Ki-1

80kD

 

anaplastic T cell leukemias, small intestine, testis, brain, not on normal lymph

brain development, implicated in ALK lymphomas

CD247

TCRz

16kD

RTK family

T, NK

TCR complex subunit, coupling of antigen recognition to signaling

CD248

TEM1, Endosialin

175kD

C-Type Lectin

endothelial tissue, stromal fibroblasts

tumor progression and angiogenesis

CD249

Aminopeptidase A

160kD

Peptidase M1 family

epith, endoth

renin-angiotensin system

CD252

OX-40Ligand, gp34

34kD

TNFSF

Bact, cardiac myocytes

T costimulation

CD253

TRAIL, Apo-2L, TL2, TNFSF10

 

TNFSF

Tact, many tissues

death

 

 

 

 

 

 

CD254

TRANCE, RANKL, OPGL

35kD

TNFSF

lymph node & BM stroma Tact

binds OPG and RANK, osteoclast differentiation, enhances DC to stimulate naïve-T proliferation

 

 

 

 

 

 

CD256

APRIL, TALL-2

16kD

TNFSF

mono, mac

binds TACI & BCMA, B proliferation

CD257

BLyS, BAFF, TALL-1

 

TNFSF

monoact, soluble form

B cell growth factor & costimulator of Ig production

 

 

 

 

 

 

CD258

LIGHT, HVEM-L

28kD

TNFSF

Tact, immature DC

binds LTBR, T proliferation, receptor for HVEM

CD261

TRAIL-R1, DR4

57kD

TNFRSF

Tact, peripheral blood leukocytes

contains death domain, apoptosis via FADD & caspase-8

 

 

 

 

 

 

CD262

TRAIL-R2, DR5

60kD

TNFRSF

widely expressed, peripheral blood lymphocytes

contains death domain, apoptosis via FADD and caspase-8

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CD263

TRAIL-R3, DcR1, LIT

65kD

TNFRSF

peripheral blood lymphocytes

receptor for TRAIL but lacks death domain

 

 

 

 

 

 

CD265

RANK, TRANCE-R, ODFR

97kD

TNFRSF

broad expression

binds TRANCE, osteoclastogenesis, T-DC interactions

CD266

TWEAK-R, FGF-inducible 14

14kD

TNFRSF

heart, placenta and kidney, HUVEC

TWEAK receptor, cell-matrix interactions and endoth growth and migration

 

 

 

 

 

 

 

 

 

 

 

 

CD267

TACI, TNFR SF13B

 

 

B, Tact

binds BAFF & APRIL

 

 

 

 

 

 

CD268

BAFFR, TR13C

25kD

TNFRSF

B

binds BLyS, mature B survival

 

 

 

 

 

 

CD269

BCMA, TNFRSF13B

20kD

TNFRSF

mature B (membrane and perinuclear)

APRIL & BAFF receptor, B survival & proliferation

CD271

NGFR, p75 (NTR)

45kD

TNFRSF

neurons (schwann cells, growing neurites), BM mesencymal cells

NGF, BDNF, NT-3, & NT-4 receptor, tumor suppressor, cell survival and death

CD272

BTLA

33kD

IgSF

Tact, B , remains on Th1

HVEM receptor, inhibitory response

CD273

B7DC, PD-L2, PDCD1L2

25kD

IgSF

DC subset, mono, mac

PD-1 receptor, costimulation or suppression of T proliferation

CD274

B7-H1, PD-L1

33kD

IgSF

leukocytes, broad

PD-1 receptor, costimulation of lymphocytes

CD275

B7-H2, ICOSL, B7-RP1, GL50

60kD

B7 Family

B, DC, mono

costimulation, cytokine production

 

 

 

 

 

 

CD276

B7-H3

40-45kD

B7 Family, ASV

in vitro cultured DC and mono, Tact, mammary tissue

costimulation, T activation

CD277

BT3.1, butyrophilin SF3 A1, BTF5

56kD

B7/BT family, ASV

T, B, NK, mono, DC, endoth, CD34+ cells, tumor cell lines

T activation

CD278

ICOS, AILIM

55-60kD

CD28 family

Tact, Th2

binds ICOS-L, T costimulation

CD279

PD1, SLEB2

55kD

 

Tact and Bact

B7-H1 & B7-DC receptor, autoimmune disease and peripheral tolerance

 

 

 

 

 

 

CD280

ENDO180, UPARAP

180kD

C-type lectin SF

chondrocytes, fibroblasts, endothelial, mac

mannose receptor, collagen matrix remodeling and endocytic recycling

CD281

TLR1

90kD

TLR family

low levels in PBMC, mono and possibly DC

innate immunity, with TLR2

CD282

TLR2

90kD

TLR family

mono, neutrophil, upregulated in mac

binds dsRNA, response to bacterial lipoproteins, innate immunity

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CD283

TLR3

100kD

TLR family, ASV

derived moDC (may be intracellular)

binds dsRNA, innate immunity

CD284

TLR4

100kD

TLR family, ASV

PBMC (weak in mono, immature DC & neutro)

binds LPS, innate immunity

 

 

 

 

 

 

CD289

TLR9

120kD

TLR family

pDC (intracellular)

binds CpG-DNA, innate immunity

CD292

BMPR1A, ALK3

57kD

Type I

bone progenitor

BMP 2 & 4 receptor, bone development

CD293

BMPR1B, ALK6

57kD

Type I, ASV

bone progenitor

BMP receptor, bone development

CD294

CRTH2. GPR44

55-70kD

GPCR-7TM

Th2, eosinophils, basophils

binds prostaglandin D2, stimulatory effects on Th2, allergic inflammation

CD295

LeptinR, LEPR

132kD

Type I cytokine-like receptor

broad

adipose metabolism, immune dysfunction in obesity

CD296

ART1, RT6, ART2

37kD

ADP- ribosyltransferase

heart and skeletal muscle, peripheral T, NK subset

modifies integrins during differentiation, ADP ribosylation of target proteins

CD297

ART4, dombrock blood group

38kD

ADP- ribosyltransferase

erythroid, monoact

ADP ribosylation of target proteins

CD298

Na+/K+-ATPase b3 subunit

52kD

 

broad

transport sodium & potassium ions across membrane

CD299

DC-SIGN-related, LSIGN, DC-SIGN2

45kD

Type II, similar to CD209, ASV

endothelial subset

binds ICAM3, HIV-1 gp120, coreceptor with DC-SIGN, HIV infection

CD300a

CMRF35H, IRC1, IRp60

60kD

IgSF, ASV

NK, mono, neutrophils, T and B subset and lymphocytic cell lines, AML

unknown

CD300c

CMRF35A, LIR

 

IgSF

mono, neutrophils, monocytic cell lines, B & T subsets

unknown

CD300e

CMRF35L

 

IgSF CMRF family

 

unknown

CD301

MGL, HML

38kD

C type lectin SF, ASV

immature DC

binds Tn antigen, uptake of glycosylated antigens

CD302

DCL1, BIMLEC

19-28kD

Type I TM C-type lectin receptor

some myeloid and Hodgkin’s cell lines

a fusion protein in Hodgkin’s lymphoma with DEC-205

CD303

BDCA2, HECL

38kD

C-type lectin SF ASV

plasmacytoid dendritic cells

inhibit IFN-alpha production

CD304

BDCA4, neuropilin 1

130kD

semaphorin family

neurons, CD4+/CD25+ Treg, DC, endothelial and tumor cells

interacts with VEGF165 & semaphorins, co-receptor with plexin, axonal guidance, angiogenesis, cell survival, migration

CD305

LAIR1

32-40kD

IgSF, ASV

NK, B, T, mono

inhibitory receptor on NK and T cells

CD306

LAIR2

 

IgSF, ASV

unknown

soluble, mucosal tolerance

CD307

IRTA2

55-105kD

IgSF (Fc receptor), ASV

B subset, B lymphoma

B cell development, translocation in some lymphomas

CD309

VEGFR2, KDR

230kD

Type III TM tyr kinase

endothelial, angiogenic precursor cells, hemangioblast

binds VEGF, regulates adhesion and cell signaling

CD312

EMR2

90kD

EGFR-7TM ASV

mono, mac, moDC, granslow

cell adhesion and migration for phagocytosis

CD314

NKG2D, KLR

42kD

Type II lectin-like receptor

NK, CD8+ activated, NK1.1+ T, some myeloid cells

binds MHC class I, MICA, MICB, Rae1 & ULBP4, activates cytolysis and cytokine production, costimulation

 

 

 

 

 

 

CD315

CD9P1, SMAP6, FPRP, PTGFRN

135kD

IgSF

B subset, monoact

with CD81 and CD9

CD316

EWI2, PGRL, CD81P3, KASP

63-75kD

IgSF8

B, T cells, low on NK cells

with CD81 & CD9; involved in cell migration

CD317

BST2, HM1.24

30-36kD

Type II

B, T, NK, mono, DC, fibroblast cell line, myeloma

pre-B cell growth, overexpressed in multiple myeloma

CD318

CDCP1, SIMA135

135kD

Type I, ASV

HSC (subset of CD34+), tumors

cell adhesion with ECM

CD319

CRACC, SLAMF7

66kD

Ig TM

T, B and DC subset, NK, upregulated in DC

regulate T and NK cells

CD320

8D6A, 8D6

30kD

LDL receptor

follicular DC, germinal centers

B proliferation, tumor formation

CD321

JAM1, F11 receptor

35kD

IgSF, Type I, ASV

platelet receptor, epithelia and endothelial, platelets

tight junctions

CD322

JAM2, VE-JAM

43kD

IgSF

HEV, other endoth

cell adhesion, lymphocyte homing to secondary lymphoid organs

CD324

E-Cadherin, Uvomorulin

120kD

cadherin SF

non-neural epith

cell adhesion, homotypic interaction & binds alphaE/b7

CD325

N-Cadherin, NCAD

140kD

cadherin SF

brain, skeletal and cardiac muscle

cell adhesion, neuronal recognition

CD326

Ep-CAM, Ly74

35-40kD

 

most epith cell membranes

growth factor receptor?

CD327

SIGLEC6

 

IgSF

placenta, spleen, B . sialic-acid dependent

adhesion, membrane- bound & secreted forms

CD328

SIGLEC7, AIRM-1

75kD

IgSF

resting and activated NK, placenta, liver, spleen, lower in gran & mono

sialic-acid dependent adhesion, inhibit NK activation, hemopoiesis

CD329

SIGLEC9

 

IgSF

neutrophils and mono

sialic-acid dependent adhesion molecule

CD331

FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM

30kD

TM tyr kinase

fibroblasts, epithelial

binds FGF, high affinity receptor for fibroblast growth factors

CD332

FGFR2, BEK, KGFR

115-135kD

TM RTK family

fibroblasts, epithelial

binds FGF, high affinity receptor for fibroblast growth factors

CD333

FGFR3, ACH, CEK2

115kD

TM RTK family

fibroblasts, epithelial

binds FGF, high affinity receptor for fibroblast growth factors

CD334

FGFR4, JTK2, TKF

110kD

TM RTK family

fibroblasts, epithelial

binds FGF, high affinity receptor for fibroblast growth factors

CD335

NKp46, Ly-94 homolog

46kD

IgSF

NK

activates NK cells upon non-MHC ligand binding

CD336

NKp44, Ly-95 homolog

44kD

IgSF

NK

activates NK cells upon non-MHC ligand binding

CD337

NKp30, Ly117

30kD

IgSF

NK

activates NK cells upon non-MHC ligand binding

CD338

ABCG2, BCRP, Bcrp1, MXR

73kD

GPCR 7TM

stem cell subset (side population)

multi-drug resistance transporter

CD339

Jagged-1, JAG1, JAGL1, hJ1

135kD

EGF TM

stromal cells, epithelial, AML

binds Notch, hematopoiesis