Human non-Cluster of differentiation (CD) Cellular Antigens

Antigen
Name

Other
Names

MW

Structure

Distribution

Function

4-1BB Ligand

CD137L

 

TNFSF

Bact, DC, carcinoma cell lines

T costimulation

AID

 

 

RNA-editing deaminase family

Bact, Germinal Center B

Activation-Induced Deaminase, Ig class switch recombination

AITR

TNFRSF18, GITR

 

 

Treg, Tact

costimulation

AITRL

TNFSF18, TL6, GITRL

 

 

APC

 

B7 family

see CD273-276

 

 

 

 

B7-H4

B7-S1, B7x

 

B7 family

 

may interact with BTLA (?), inhibition

BAMBI

TGFBR

29kD

TGFBR

carcinoma cell

pseudoreceptor for TGF-b (short cytoplasmic domain), growth inhibition

BCMA

see CD269

 

 

 

 

BLyS

see CD257

 

 

 

 

BR3

see CD268

 

 

 

 

BTLA

see CD272

 

 

 

 

CCR7

see CD197

 

 

 

 

c-Met

HGFR/SFR

190kD

heterodimer, PTK

epith, hematopoietic progenitors, early thymocytes

tumor growth / metastasis, Hepatocyte Growth Factor / Scatter Factor receptor, T development, hematopoiesis

CMKLR1

chemokine-like receptor 1

42kD

GPCR 7TM, chemokine receptor

pDC (CD123+), in vitro derived moDC

binds chemerin, pDC recruitment, bone development

DcR3

TR6, TNFRSF6B

 

Soluble

tumors

Fas decoy receptor, tumor evasion

 

 

 

 

 

 

DEC-205

see CD205

 

 

 

 

DR3

TRAMP, Apo-3, WSL-1, LARD, TR3

 

TNFRSF

Tact, leukocytes

lymphocyte homeostasis

 

 

 

 

 

 

DR6

TR7

 

TNFRSF

 

death, Th2 response

Fc epsilonRI alpha

high-affinity IgE receptor

 

tetramer complex

mast cells, basophils

triggers IgE-mediated allergic reactions

Foxp3

SCURFIN

50kD

Fox family forkhead

T subsets (CD4+/CD25+ subset and CD8+ subset)

transcription factor, upregulated in T regs

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Granzyme B

Granzyme-2, CTLA-1

30kD

Peptidase S1 family

Cytotoxic T, NK

target cell apoptotic lysis, cell-mediated immune responses

HLA-ABC

 

45, 11-12kD

 

nucleated cells

cell-mediated immune response & tumor surveillance

HLA-DR

 

 

 

APC, Tact

presentation of peptides to CD4+ T lymphocytes

HVEM

TNFRSF14, TR2

60kD

TNFRSF

broad expression

receptor for LIGHT, LT-alpha, BTLA, Herpes Simplex Virus, lymphocyte activation

ICOS

see CD278

 

 

 

 

ICOSL

see CD275

 

 

 

 

IL-15R alpha

 

 

 

monoact

binds to IL-15, w/ IL-2RB and common gamma, IL-15 trans-presentation

Integrin b5

 

100kD

 

carcinoma cell lines, fibroblast lines

w/ alphav subunit, vitronectin receptor

MD-2

 

30KD

 

w/ TLR4 distribution and LPS recognition

 

MICA/MICB

 

70kD

MHC Class I-related proteins

intestinal epith, some tumors

unregulated on epith after shock, NKG2D receptors

Nanog

 

34kD

 

ES cells

transcription factor, self renewal of ES cells

 

 

 

 

 

 

NKG2D

see CD314

 

 

 

 

NOD2

CARD-15, IBD1

 

 

monocytes, intracellular

 

Notch-1

Lin-12, Tan 1

 

 

developing embryo, variety of adult tissues

cell-cell interaction, cell fate determination

OPG

TRAIL-R5, TR1, TNFRSF11B

 

 

binds TRAIL?

bone resorption

OX-40

see CD134

 

 

 

 

OX-40 Ligand

see CD252

 

 

 

 

p38

 

38kD

SAP/MAP kinase

NK, CD8+ T subset, upregulated on CD8+T

role in cytolytic activity

PD-1

see CD279

 

 

 

 

PD-L1

see CD274

 

 

 

 

PD-L2

see CD273

 

 

 

 

Perforin

 

70-75kD

 

CTL, NK

cytolytic protein

 

 

 

 

 

 

RP105

see CD180

 

 

 

 

RANK

see CD265

 

 

 

 

RANKL

see CD254

 

 

 

 

SAP

SLAM-associated protein

14kD

adaptor protein

T, NK

negatively regulates SLAM- family receptors

SLP-76

 

76kD

 

T, Blow

T cell receptor mediated signaling

SSEA-1

stage-specific embryonic antigen-1

 

 

ES cells, embryonic carcinomas, germ cells

down regulated by differentiation

SSEA-3

stage-specific embryonic antigen-3

 

 

 

 

SSEA-4

stage-specific embryonic antigen-4

 

 

 

 

Stro-1

 

 

 

BM stroma, erythroid progenitors

surface marker for immature mesenchymal cells

TACI

see CD267

 

 

 

 

T-bet

 

 

 

Th1 cells

transcription factor, T development / differentiation

TCL1

 

 

 

B cell tumors, lymphoid lineages in a developmentally controlled manner, pDC

intracellular, lymphoid proto-oncogene

TCR alpha b

 

 

 

peripheral T subset

antigen recognition

TCR gamma delta

 

 

 

T subset

antigen recognition

TLR1 - TLR4

see CD281 - CD284

 

 

 

 

TLR5

TIL3

 

TLR family

mRNA: leukocytes, prostate, ovary, liver, lung

interacts w/ microbial lipoproteins, NF-kappaB, responds to Salmonella

TLR6

 

 

TLR family

mRNA: leukocytes, ovary, lung

interacts w/ microbial lipoproteins, protein sequence similar to hTLR1; regulates TLR2 response

TLR7

 

 

TLR family

mRNA: spleen, placenta, lung; upregulated on mac

 

TLR8

 

 

TLR family

mRNA: leukocytes, lung

 

TLR9

see CD289

 

 

 

 

TLR10

 

 

TLR family

mRNA: lymphoid tissues

most closely related to TLR1 and TLR6

TNFRI

see CD120a

 

 

 

 

TRAIL

see CD253

 

 

 

 

TSLPR

 

50kD

heterodimer with IL-7Ralpha/CD127

monocytes, DC, B

binds TSLP (Thymic Stromal Lymphopoietin) to activate DC

TWEAK

TNFSF12, APO3L

 

TNFSF

activated mono

death

 

 

 

 

 

 

TWEAK Receptor

see CD266

 

 

 

 

ULBPs

 

 

MHC class I-related protiens, GPI-linked

tumors

NKG2D receptors, NK activation

ZAP-70

TCRζ-associated kinase

70kD

Syk family

Intracellular T, NK

TCR signaling & development

 Source: http://www.ebioscience.com/resources/human-cd-chart.htm#human-cd-chart

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